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National Repository of Grey Literature

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	Polymerní konjugát doxorubicinu na bázi HPMA, působící ve shodě s protinádorovou imunitou nositele Šírová, Milada ; Rossmann, Pavel ; Mrkvan, Tomáš ; Strohalm, Jiří ; Šubr, Vladimír ; Plocová, Daniela ; Ulbrich, Karel ; Říhová, Blanka Polymeric conjugate Dox-HPMA-HuIg directly targets the tumour due to the EPR effect, it is not detrimental towards the immune system of the host, and acts in concert with the anti-tumour immune responses Detailed record
	Glykosylace povrchové membrány EL-4 buněk: vliv volného nebo N-(2-hydroxypropyl)methacrylamide (HPMA) vázaného doxorubicinu Kovář, Lubomír ; Etrych, Tomáš ; Šubr, Vladimír ; Strohalm, Jiří ; Sklenář, Jan ; Chytil, Petr ; Ulbrich, Karel ; Říhová, Blanka In those experimenst we studied the possible impace of CD43 as highly glycosylated molecule in cells exposed to free doxorubicin (Dox) or to conjugates consisting of HPMA copolymer backbone to which the drug is conjugated via enzymatically (PK1 conjugate) or pH sensitive, hydrolytically cleavable bond (hydrazone conjugate, HYD). Detailed record
	Protilátka anti-DR5 vázaná na HPMA: nový přístup k imunochemoterapii nádorů Říhová, Blanka ; Hovorka, Ondřej ; Kopečková, P. ; Kopeček, J. Dimerized antibodies anti-DR5 bound to the synthetic polymer based on HPMA, effectively induce apoptosis of the tumor cells that express TRAIL on their surface. At the same time, the tumor cells are also targeted by cytotoxic drug +doxorubicin bound to the HPMA polymeric conjugate Detailed record
	Indukce efektivní protinádorové imunity při léčbě směrovaným konjugátem na bázi poly(HPMA) obsahujícím doxorubicin Kovář, Marek ; Tomala, Jakub ; Mrkvan, Tomáš ; Etrych, Tomáš ; Strohalm, Jiří ; Ulbrich, Karel ; Říhová, Blanka Thus, treatment with B1 mAb-targeted conjugates is able to completely cured BCL 1 bearing mice and most importantly, break immunoescaping mechanisms of BCL1 cells Detailed record

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